The Jaguars are listed as +3 underdogs versus the 49ers, with +100 at BetMGM the best odds currently available.įor the favored 49ers (-3) to cover the spread, PointsBet has the best odds currently on offer at -110.īetMGM currently has the best moneyline odds for the Jaguars at +145, which means you can bet $100 to profit $145, earning a total payout of $245, if they win. Odds are correct at the time of publication and subject to change. We have researched the best betting odds in America for this game, which are listed here: Based on advanced machine learning and data, has simulated the outcome of Sunday's 49ers-Jaguars NFL matchup 10,000 times.ĭimers' proven predictive analytics model, DimersBOT, currently gives the 49ers a 59% chance of beating the Jaguars in Week 10 of the NFL season.